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Periodontal Disease and Systemic Disease
about periodontal disease
In this column, we will reply to questions about periodontal disease, monthly. We hope you can learn correctly what periodontal disease in connection with your health is, and refer to it for your life.
CONTENTS INDEX
The 2nd time basic knowledge of gum disease
Q1.  What are the symptoms of periodontal disease?  »
Q2.  Is gingival bleeding caused by periodontal disease?  »
Q3.  Is periodontal disease preventable with a good brushing? »
Q1:What are the symptoms of periodontal disease?

A1:
Periodontal disease develops very slowly and changes in the mouth are often left undetectable. It is not unusual for patients even with advanced stage of periodontitis to detect little subjective symptoms. In many cases, patients become aware of the disease when their teeth become loose due to the destruction of their alveolar bones.
The clinical symptoms of periodontal disease may vary depending on the level of its progress. Some of the common symptoms are red tender gums, somewhat swollen gums, gum predisposed to bleeding, bad breath, gum susceptive to irritation, loose tooth, sticky saliva, receding gums, and loss of teeth.

Periodontal tissues affected by periodontitis leads to inflammation in order to counteract the bacteria. Inside the inflamed periodontal tissue, the following reactions are caused in phase. Periodontal disease is "the disease that gradually destructs periodontal tissues" and various symptoms are developed according to the phases.


1)Initial stage of periodontal disease(gingivitis)
Neutrophiles (a kind of white blood cells) multiplies counteracting proliferated periodontal bacteria within gingiva. In order to supply neutrophiles to gingiva, there are increased numbers of capillary blood vessels in gingival tissues, resulting redness is reflected on gingival margins.

Detailed contents
Pathogenic bacterial flora Elimination of bacteria by neutrophiles Invasion of bacteria


2) Early stage of periodontitis
As the periodontal bacteria increase, neutrophiles incorporate macrophages and lymphocytes to defend the periodontal tissues through their immune system. The defense cells in gingival tissues multiply as their inflammation advances and the symptoms of initial stage, such as gingival swelling and bleeding from gingival sulcus , become more prominent.

*What is macrophage? : It is a bone marrow-derived monocyte, which reach tissues and grows to relatively large cell with phagocytoses. It defends the host tissues against the invasion of harmful bacteria and foreign bodies, and restores the damaged parts, besides its function similar to that of their neutrophil, which phagocytoses (captures, digests and kills) bacteria and viruses, it also carries down as antigens the information of invasive bacteria to lymphocyte and functions as regulators of the immune response. Macrophage is a very important cell that plays an essential role in host defense system.

Detailed contents
Production of inflammatory cytokines and mediators Inflammation and destruction of tissue


3) Developmental stage of periodontitis
Periodontal pockets can be seen visually. In this stage, overall destruction of periodontal tissues (gingival epithelium, gingival connective tissue, cementum, alveolar bone) begins.



4)Establishment of periodontal disease
Ulcer appears in gingiva and destruction of alveolar bone advances. Typical symptoms of periodontal disease, such as manifestation of gingival redness and swelling, gingival swelling susceptive to irritation, bleeding, exudates and pus discharge from periodontal pockets, bad breath, gingival recession, sticky salvia, loose tooth, loss of teeth etc. appear.

Illustration offer: Okayama University
CONTENTS INDEX
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